Estrogen Resistance Syndrome
Estrogen resistance syndrome is a rare, genetic endocrine disease characterized by estrogen-receptor insensitivity to estrogens and the presence of elevated estrogen and gonadotropin serum levels. Clinical manifestations include absent breast development and primary amenorrhea in association with multicystic ovaries and/or hypoplastic uterus in female patients, normal or abnormal gonadal development in male patients and markedly delayed bone maturation, persistence of open epiphyses, reduced bone mineral density, and variable tall stature in both sexes. Glucose intolerance, hyperinsulinemia and lipid abnormalities may also be present.
The two main factors that seem to contribute to insulin resistance and hyperinsulinemia are excess body fat, especially around your belly, and a lack of physical activity.
Excess body fat per se is probably incorrect. My best understanding is lack of muscle mass and thus lack of protein availability is probably a factor in insulin resistance and, critically, dying of starvation is about running out of adequate muscle mass.
Page two of The underappreciated role of muscle in health and disease [PDF] suggests that fat per se is not the explanation for insulin resistance and somewhere in this paper it talks about the mechanism by which starvation occurs.
Glucose intolerance is basically prediabetes. I've read a lot about diabetes in the past because I'm at high risk of a form of diabetes. It's strongly associated with inflammation which MAY suggest infection of some sort or MAY suggest excess acidity and excess acidity promotes infection.
The gallbladder produces bile which is how we digest fat or a factor in how we digest fat and estrogen begins with cholesterol and estrogen resistance syndrome can be associated with lipid abnormalities, so I would have to wonder if there's been a work up on gallbladder function and probably not but I would wonder about that connection.
CF is fundamentally a salt wasting condition and significantly impairs the processing of triglycerides. I've done NOTHING per se to treat my blood sugar issues but my blood sugar issues have improved substantially, likely a consequence of treating inflammation and infection. I've also not consciously and intentionally treated my gallbladder but my love-hate relationship with vomiting is probably improved bile production promoting vomiting. When I vomit on an empty stomach, it's always a very bad day and it tastes bitter or sour, tends to look orange and I'm probably vomiting bile.
This is not medical advice. This is a potential avenue for investigation seeking to understand the mechanism behind estrogen resistance.