A ramble about marijuana as if I've been toking though, no, I haven't.

Effects of estrogen on retinal degeneration

The top comment seems to have some good information about estrogen and RD and to MY mind it's pertinent to my hypothesis that trans people have a sex hormone syndrome that impairs health in important ways. 

OP also mentions eye pressure. I have one eye that bulges a bit compared to the other and it used to be worse and I was personally acquainted with someone with "frog eyes" and I suspect they were a heavy user of illicit drugs.

I am allergic to marijuana and have broken out in hives when exposed to sufficient amounts second hand via residue on surfaces or smoke. 

I did a college level paper on Functional Hypoglycemia at age seventeen for an AP class requiring me to research it and cite it to the rigorous standards of a college class because I had begun trying to deal with my undiagnosed health issues as early as age fourteen and that's actually the source of my interest in and knowledge of vegetarianism: I began trying to eat better as young as age fourteen to manage my health problems that were being largely dismissed as hypochondria.

Anyway, I cleaned up my diet to manage my blood sugar issues and that did help. One of my symptoms was blacking out when I stood up too fast and I was attributing that ENTIRELY to my blood sugar issues and it absolutely was triggered by me laying in bed reading and not eating enough before jumping up to rush down the hall and finding myself momentarily with no vision and occasionally on the floor.

So I avoided sugar very studiously for a few years and my blood sugar issues improved and I largely stopped blacking out. Naturally, I attributed my lack of blackouts entirely to improving my blood sugar.

The in my forties, I learned that standing up too fast and blacking out is a symptom of orthostatic hypotension and reexamined my life and drew other conclusions because orthostatic hypotension is a known side effect of marijuana and my brother was a marijuana user.

In fact, he took up smoking relatively late in life for the express purpose of covering up the smell of marijuana and the fact that he was using it.

I once not only blacked out momentarily from standing up too fast after not eating, I found myself face down on the floor with my head swirling with psychedelic imagery for a few minutes.

So in my forties I concluded that my blackouts in adolescence were due to my brother secretly using drugs in the same house I was living in including but probably not limited to marijuana.

Since then, I have had enough second hand exposure to marijuana to feel confident this conclusion is correct. My tendency to black out when I stand up too fast is correlated to exposure or to times when I have reason to believe old residues are coming out of my system.

Anyway, a search for marijuana and bulging eyes gets me this:

Marijuana, particularly its active ingredient, THC, causes blood vessels in the eyes to expand, leading to increased blood flow. This vasodilation is the primary culprit behind those bloodshot eyes that become the telltale sign you’ve been enjoying some green. 

And also this: Cannabis Linked to Bulging Eyes in Graves' Disease

A search for effect of marijuana on eye pressure gets me:

Marijuana has been found to temporarily lower pressure in the eye, or intraocular pressure. This effect is due to the active ingredient tetrahydrocannabinol (THC). THC relaxes and dilates blood vessels, allowing more blood to flow, which has the same pressure-reducing effects in the eye. However, this effect only lasts for a short period of time, about three or four hours. Cannabis also lowers blood flow to the optic nerve, which can cause more optic nerve damage and worsen glaucoma. 

Cannabis and currently available compounds derived from marijuana like CBD are not an adequate treatment for glaucoma, or any eye condition. To treat glaucoma, eye pressure must be managed 24 hours a day. Marijuana is not a practical treatment for constant use. 

So OFFICIALLY what the medical establishment CLAIMS is that it lowers blood pressure in the eyes -- thus leading to bloodshot eyes -- and is not adequate treatment for glaucoma (and may actually worsen it) but I can't help but wonder if increasing blood flow promotes that extremely LOVELY "frog eye" look that someone I knew and hated had.