Depression After HRT Starts

I read a question somewhere by someone super depressed after starting HRT and jotted down the following thoughts without the link:

If my hypothesis is correct that HRT improves immune function in a body impaired by mismatch between physiology and hormones and going on HRT doesn't alleviate feelings of hopelessness or pointlessness or even makes them worse: trypanosomiasis is underdiagnosed and die off causes feelings of hopelessness and pointlessness.

Additional symptoms include waking up with black crud under your fingernails. The infection is treatable and cinnamon may help mitigate the emotional fallout, just don't overdo it because cinnamon is also a blood thinner.

Footnote 

Originally published elsewhere on 04/28/25.